FIG 2.
High-throughput screening hits of EC83 mimics with the strongest cytotoxicity compared to other NPECS tRF mimics on HCT-8 cells. (A) Heatmap of high-throughput screening of 82 tRF mimics with hits of 12 tRF mimics with potency in reducing the cell viability of HCT-8 cells. (B) Dose-dependent investigations of the top 12 hits of tRF mimics. (C) IC50 values with standard deviations for the top 12 hits of tRF mimics showing that the EC83 mimic has the strongest cytotoxicity against HCT-8 cells.