FIG 5.

Gm modification increases the inhibitory effects of EC83 mimics on colony formation and migration of CRC cells, while s⁴U does not. (A) Clonogenic assay of the EC83 mimic, the EC83-M1 mimic, the EC83-M2 mimic, and the EC83-M3 mimic on HCT-8 and LoVo cells. (B) Wound-healing assay of the EC83 mimic, the EC83-M1 mimic, the EC83-M2 mimic, and the EC83-M3 mimic on HCT-8 and LoVo cells. Data are shown as the means ± SD from three independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 (by two-tailed Student’s t test).