FIG 6.

Gm modification increases the inhibitory effects of EC83 mimics toward CRC tumor growth in vivo. (A) Growth rates of tumors with the encapsulated EC83 mimic and the EC83-M2 mimic, 5-FU, or HKP alone as a control. (B) Weights of tumors removed from the mice after day 22. (C) Images of each tumor in all groups. (D) Body weights of mice in all groups. (E and F) Representative images of hematoxylin and eosin-stained tumors (E) and major organs (F) of CRC xenograft-bearing nude mice in all groups. Data are shown as the means ± standard errors of the means (SEM). *, P < 0.05; ***, P < 0.001; ****, P < 0.0001 (by two-tailed Student’s t test).