. 2021 Sep 1;11(47):29267–29286. doi: 10.1039/d1ra05268c

3D pictures representing the binding interactions and positioning of the tested natural compounds (1–6) inside both S and Mpro pockets of the SARS-CoV-2, besides the N3 inhibitor of Mpro (redocked, 7)^a.

Comp.	Pocket	3D interactions	3D protein positioning
1	S
1	Mpro
2	S
2	Mpro
3	S
3	Mpro
4	S
4	Mpro
5	S
5	Mpro
6	S
6	Mpro
N3, 7	Mpro

H-bonds were represented by red dashed lines while H-pi bonds by black ones.

3D pictures representing the binding interactions and positioning of the tested natural compounds (1–6) inside both S and Mpro pockets of the SARS-CoV-2, besides the N3 inhibitor of Mpro (redocked, 7)a.