Figure 5.

Structural indices of disease-specific networks. (A) Heatmap showing the modularity of the IBS-specific co-abundance network. (B) Heatmap showing the modularity of the IBS-specific co-abundance network after removing viral nodes. (C) Log2-transformed node degree distribution. Node degree is the number of direct links of a node. Degree distribution of a scale-free network follows a power-law distribution, and after log–log transformation, the distribution should fit a linear relationship. The r-square of each line is defined as the scale-free index. In each subgraph, R1 represents the line of all the nodes, R2 represents the line of nodes excluding eukaryotic viruses, R3 represents the line of nodes excluding phages, and R4 represents the line of nodes excluding all viruses. (D) Average path lengths of the pan-disease-specific network in family level. Viruses were added to the bacteria network in the decreasing order of betweenness centrality.