Skip to main content
[Preprint]. 2022 Apr 20:rs.3.rs-1431484. [Version 1] doi: 10.21203/rs.3.rs-1431484/v1

Figure 5. Diagram of proposed working hypothesis of CD147 in SARS-CoV-2 Infection.

(1) SARS-CoV-2 virions infect human cells via the canonical pathway where host Angiotensin-converting Enzyme 2 (ACE2) receptors bind to viral spike proteins (red) and facilitate viral entry and infection. (2) CD147 proteins, via binding to surface binding partners (e.g., E-selectin), facilitate cell-cell adhesion, membrane fusion, and intercellular transfer of SARS-CoV-2 virions. (3) Erythrocytes and platelets which strongly express CD147, bind SARS-CoV-2 virions, and increase thrombosis risk and other clinical manifestations of COVID-19.