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. 2022 Mar 22;13:848681. doi: 10.3389/fphys.2022.848681

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Copyright © 2022 Taylor, Lowery, Choi and Francis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV4 channel expression in human peripheral arteries (A) Immunofluorescence staining of TRRV4 (red) in cross-sections of nCVD and CVD peripheral arteries. Green is autofluorescence (Auto); Bar 500 µm. Panels to the right show autofluorescence (including internal elastic lamina; IEL), TRPV4, and merged signals. Images of the arterial walls of three different vessels show TRPV4 expression within the intima (I) and media (M). Expression was also detected in the neointima (NI) of all CVD arteries evaluated. Bottom panel shows secondary antibody-only control (No primary Ab); Bar is 50 µm (B) Lectin staining (white) showed consistent endothelial staining along the arterial intima, including vessels with developed neointima (cell nuclei indicated in blue); Bar is 20 µm. Data are representative from four separate samples.