FIGURE 5.

Impact of TRPV4 channel activation on dynamic Ca²⁺ signaling (A) Panels show cumulative (60 s) masks of nCVD and CVD arteries before and after 5-min treatment with 30 nM GSK1016790A. Tracings of individual tracked event centers are shown on the right and a summary of parameter distributions before and after GSK1016790A exposure is plotted below. Time-projected x-y plots of representative vessel preparations are shown on the right. Colors show relative event positions along the y-axis (B) Overlapping histograms of Ca²⁺ event parameter distributions and difference plots, showing the relative impact of GSK1016790A treatment and differences between CVD and nCVD arteries. Data were acquired from five different tissue samples. Asterisk * indicates p < 0.05.