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Proposed model of E. chaffeensis TRP120 Notch activation. A TRP120-TR Notch SLiM memetic motif (TRP120-N1-P6; yellow highlight) binds the Notch-1 extracellular domain at a region containing the confirmed Notch ligand-binding domain (LBD) to activate Notch signaling. TRP120-N1-P6 binding leads to NICD nuclear translocation and upregulation of Notch gene targets.
