FIG 1.

Differences in antibody binding between Delta-infected individuals and COVID-19-vaccinated individuals experiencing delta breakthrough infection. (A) Difference in IgG and IgM titers for sera collected 12 to 22 days POS for the Delta infection (vaccine-naive) group. (B) Comparison of the IgG and IgM ED₅₀ values against recombinant WT and Delta spikes for the vaccine-naive group. (C) Difference in IgG and IgM titers for sera for the BTI group. Sera were collected 12 to 22 days POS. (D) Comparison of the IgG and IgM ED₅₀ values against recombinant WT and Delta spikes for the BTI group. (E) Longitudinal IgG ED₅₀ against recombinant Delta spike in the BTI group. (F) Longitudinal IgM ED₅₀ against recombinant Delta spike in the BTI group. Donors with IgM > IgG are shown in blue, donors who did not seroconvert are shown in red, donors with high spike IgG but no N IgG at <7days POS are shown in orange, and donors with low spike IgG at <7 days POS that rapidly increased are shown in yellow. P values were calculated using a Wilcoxon matched-pair signed rank test.