FIG 3.

Comparative compositions of the gut microbiomes of young and old mice. (A) Relative abundances of taxa at the phylum level show that Firmicutes and Bacteroidetes dominate the microbial communities in both young and aged mice. (B) A forest plot of the ratio of the Firmicutes phylum to the Bacteroidetes showed no significant alteration between young and old mice. (C) Taxa significantly enriched by age on combined data sets. For panels B and C, the combined analysis was performed using a linear mixed-effects model using the formula log₂FC ∼ age + (1|study). The Benjamini-Hochberg method was used to correct for multiple comparisons. A P value of <0.05 was considered statistically significant.