Figure 6.

Cardioprotection of remote conditioning by rhythmic compression is lost in SCH or MRS treated rats and mimicked by BAY and CGS treatment. (A) Schematic diagram of the experimental design. RCRC group were treated with the selective A2a antagonist SCH 58261, the selective A2b antagonist MRS 1706; CON group treated with the selective A2a agonist CGS21680 and the selective agonist A2b agonist BAY 60-6583. (B,C) TTC staining representing infarct area on multiples slices of an infarct rat heart and quantitative analyses of infarct size after 3 days of remote conditioning in combination with A2a and A2b receptor blockage and activation, N = 6. (D–H) Representative M-mode echocardiographic images showing LV wall motion of the hearts, the treatment effect was calculated as the changes of LVEFs and LVFSs from baseline to endpoint in combination with A2a and A2b receptor blockage and activation. All values represent as means ± SD. N = 6. *p < 0.05, **p < 0.01, ****p < 0.0001 vs. CON.