TABLE 1.

Mutations characteristic of the outbreak clade originating from the node labeled C in Fig. 2B^a

Position in VRE_5_P5 (bp)	Position in Aus0004 (bp)	Type	Length (bp)	Effect	Nucleotide change	Amino acid change	Gene	Protein
60123	95524	SNP	1	Missense variant	2032G>A	Val678Ile	fusA	Elongation factor G
389298	416003	ins	12	Conservative inframe insertion	536_537insCGAAGACAGCAA	Asn179_Glu180, ins, GluAspSerAsn	malP	Glycoside hydrolase, family 65
1666026	1271778	del	1	Frameshift variant	1187delA	Lys399fs	mvaE	Hydroxymethylglutaryl-coenzyme A reductase
1672764	1278516	SNP	1	Missense variant	59C>A	Ala20Asp	cls	Cardiolipin synthase
2013711	2022517	SNP	1	Missense variant	1261G>A	Ala421Thr	brnQ	Branched-chain amino acid transport system II carrier protein
pl1, 184545	—	del	63	—	—	—		—

^aThe mutation with no effect (—) was in an intergenic region on plasmid 1 (pl1). All other mutations were chromosomal and nonsynonymous. Del, deletion; ins, insertion.