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. 2022 Mar 14;13(2):e02983-21. doi: 10.1128/mbio.02983-21

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Copyright © 2022 Alymova et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Glycome modifications reduce the immunogenicity of H3N2 IAV in mice. (a to d) Mice were immunized with 10.0 μg of HA from A(H3N2)2013 IAV with reduced or unmodified glycosylation of its HA and NA. (a and c) Pooled antibody titers from days 35 and 43 (n = 9 to 15) and (b) antibody titers for day 35 (n = 6 to 9) are shown. (a) HA and (b) NA total homologous and cross-reactive antibody titers were measured by ELISA using as antigen recombinant HAs and NAs from the indicated A(H3N2) IAV strain. (c and d) Homologous and cross-reactive HA antibody titers were determined by (c) HI and (d) neutralization assays with a panel of A(H3N2) IAV. Data represent the average (± SD) of two independent assays run in duplicate. Significant differences between groups: *, P < 0.05; **, P < 0.005; ***, P < 0.0005.