FIG 3.

AZL proteins found in characterized Streptomyces biosynthetic gene clusters. (A and B) Gene diagrams for AZL-containing BGCs producing DNA alkylating agents (A) and compounds not known to alkylate DNA (B). Gene names are labeled below the cluster diagrams. The biosynthetic scaffold produced by specific genes in the cluster is shaded gray and labeled above the respective genes. NRPS, nonribosomal peptide synthetase; PKS1/PKS2, type 1/2 polyketide synthase; (PKS), PKS-like. Chemical structures of the metabolites produced by each cluster are shown at the bottom of each panel.