Table 1.
Experimental runs, independent and dependent variables of the 32 full factorials experimental design of Magnesium ascorbyl phosphate-loaded ethosomes.
| Runs* | Factors (Independent variables) |
Responses (Dependent variables) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Ethanol % (v/v) (mL/100 mL) | PC % (w/v) (g/100 mL) | Y1:E.E (%) | Y2: Particle size (nm) | Y3:PDI | Y4:ZP (mV) | Y5: % permeated (8 h) | |||
| FE1 | (−1) | 30 | (−1) | 1 | 51.45 ± 2.34 | 148.62 ± 15.27 | 0.496 ± 0.071 | −32.24 ± 5.24 | 38.12 ± 2.61 |
| FE2 | (−1) | 30 | (0) | 2 | 65.56 ± 1.56 | 158.73 ± 18.53 | 0.482 ± 0.054 | −33.42 ± 3.45 | 33.24 ± 1.93 |
| FE3 | (−1) | 30 | (1) | 3 | 60.71 ± 2.04 | 167.42 ± 12.37 | 0.480 ± 0.123 | −31.47 ± 5.34 | 31.80 ± 2.52 |
| FE4 | (0) | 40 | (−1) | 1 | 63.43 ± 3.17 | 157.27 ± 17.63 | 0.415 ± 0.142 | −29.37 ± 3.74 | 51.62 ± 2.14 |
| FE5 | (0) | 40 | (0) | 2 | 70.32 ± 2.86 | 163.47 ± 10.46 | 0.375 ± 0.085 | −26.72 ± 2.64 | 42.83 ± 3.51 |
| FE6 | (0) | 40 | (1) | 3 | 66.67 ± 3.46 | 183.37 ± 20.46 | 0.262 ± 0.053 | −30.28 ± 4.72 | 40.92 ± 2.13 |
| FE7 | (1) | 50 | (−1) | 1 | 83.43 ± 2.23 | 160.57 ± 13.74 | 0.257 ± 0.008 | −35.91 ± 4.08 | 68.47 ± 3.60 |
| FE8 | (1) | 50 | (0) | 2 | 86.14 ± 1.58 | 180.63 ± 11.42 | 0.237 ± 0.014 | −32.92 ± 3.81 | 61.91 ± 2.94 |
| FE9 | (1) | 50 | (1) | 3 | 76.47 ± 3.51 | 193.52 ± 10.58 | 0.222 ± 0.047 | −36.64 ± 3.64 | 57.52 ± 2.50 |
*MAP (0.3% w/v (0.333 g/100 mL)) and PG (10% v/v (10 mL/100 mL)) were kept constant in all formulations, volume was completed up to 100 mL with distilled water. EE: Entrapment Efficiency, PDI: Polydispersity index, ZP: Zeta potential.