Table 2.

Experimental runs, independent and dependent variables of the 2³ full factorials experimental design of Magnesium ascorbyl phosphate-loaded niosomes.

Runs*	Factors (Independent variables)					Responses (Dependent variables)
	Surfactant type	Surfactant molar ratio		Cholesterol molar ratio		Y1:EE (%)	Y2: Particle size (nm)	Y3:PDI	Y4:ZP (mV)	Y5: % permeated (8 h)
FN1	Span 60	(−1)	1	(−1)	1	69.80 ± 3.56	218.60 ± 22.52	0.253 ± 0.124	−26.83 ± 3.34	36.67 ± 3.64
FN2	Span 60	(−1)	1	(+1)	2	78.63 ± 2.47	258.23 ± 16.85	0.281 ± 0.092	−32.42 ± 2.58	30.14 ± 1.96
FN3	Span 60	(+1)	2	(−1)	1	86.82 ± 4.52	138.43 ± 17.84	0.312 ± 0.112	−27.56 ± 2.67	54.42 ± 2.35
FN4	Span 60	(+1)	2	(+1)	2	92.13 ± 3.09	169.32 ± 12.22	0.292 ± 0.163	−31.42 ± 2.43	46.37 ± 3.24
FN5	Span 80	(−1)	1	(−1)	1	53.85 ± 4.52	362.43 ± 24.63	0.415 ± 0.131	−25.82 ± 4.52	33.34 ± 2.05
FN6	Span 80	(−1)	1	(+1)	2	61.24 ± 2.68	384.62 ± 14.52	0.281 ± 0.082	−32.63 ± 3.84	28.46 ± 2.98
FN7	Span 80	(+1)	2	(−1)	1	68.32 ± 2.97	278.40 ± 10.58	0.354 ± 0.028	26.08 ± 3.06	50.58 ± 2.68
FN8	Span 80	(+1)	2	(+1)	2	87.32 ± 3.12	315.62 ± 11.23	0.382 ± 0.036	−30.52 ± 2.41	40.42 ± 3.21

*MAP (one molar ratio) was kept constant in all formulations. EE: Entrapment Efficiency, PDI: Polydispersity index, ZP: Zeta potential.