Standardization of reaction conditions for the synthesis of 3,3′-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones).
| Entry | Catalyst (mol%) | Solvent | Time (h) | Yield (%) |
|---|---|---|---|---|
| 1 | No catalyst | Solvent-free | 24 | Nil |
| 2 | No catalyst | EtOH | 6 | 22 |
| 3 | Camphor sulfonic acid (20 mol%) | EtOH | 6 | 78 |
| 4 | Camphor sulfonic acid (20 mol%) | MeOH | 6 | 72 |
| 5 | Camphor sulfonic acid (20 mol%) | H2O | 6 | 61 |
| 6 | Camphor sulfonic acid (20 mol%) | EtOH : H2O (1 : 1 v/v) | 2 | 94 |
| 7 | Camphor sulfonic acid (15 mol%) | EtOH : H2O (1 : 1 v/v) | 2 | 86 |
| 8 | Camphor sulfonic acid (20 mol%) | EtOH : H2O (1 : 1 v/v) | 2 | 94 |