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. 2021 Sep 1;11(47):29130–29155. doi: 10.1039/d1ra04887b

Standardization of reaction conditions for the synthesis of 3,3′-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones).

Entry Catalyst (mol%) Solvent Time (h) Yield (%)
1 No catalyst Solvent-free 24 Nil
2 No catalyst EtOH 6 22
3 Camphor sulfonic acid (20 mol%) EtOH 6 78
4 Camphor sulfonic acid (20 mol%) MeOH 6 72
5 Camphor sulfonic acid (20 mol%) H2O 6 61
6 Camphor sulfonic acid (20 mol%) EtOH:H2O (1:1 v/v) 2 94
7 Camphor sulfonic acid (15 mol%) EtOH : H2O (1 : 1 v/v) 2 86
8 Camphor sulfonic acid (20 mol%) EtOH : H2O (1 : 1 v/v) 2 94