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. 2021 Sep 1;11(47):29130–29155. doi: 10.1039/d1ra04887b

Effect of solvents and temperature on the synthesis of substituted coumarins.

Entry Solvent Temperature (°C) Time (min) Yield (%)
1 — 90 75 72
2 CHCl3 Reflux 200 35
3 CH3CN Reflux 200 10
4 CH2Cl2 Reflux 200 20
5 THF Reflux 200 0
6 MeOH Reflux 200 0
7 H2O Reflux 200 0
8 — 70 120 70
9 — 110 25 91
10 — 130 25 92