TABLE 1.
Patient characteristics
| Thyroid cancer cohort | Thyroid cancer only | Thyroid and breast cancer | Breast cancer only | |
|---|---|---|---|---|
| n | 3214 | 947 | 1542 | 78,141 |
| Age at diagnosis a : median (IQR) in years | 45 (35.55) | 40 (32.49) | 48 (38.57) | 48 (41.56) |
| Sex | ||||
| Female | 2969 (92.4) | 881 (93.0) | 1528 (99.1) | 77,423 (99.1) |
| Male | 245 (7.6) | 66 (7.0) | 14 (0.9) | 718 (0.9) |
| Self‐reported race and ethnicity | ||||
| African American | 113 (3.5) | 28 (3.0) | 63 (4.1) | 6315 (8.1) |
| Ashkenazi Jewish | 268 (8.3) | 94 (9.9) | 122 (7.9) | 4058 (5.2) |
| Asian | 111 (3.5) | 27 (2.9) | 60 (3.9) | 3938 (5.0) |
| Hispanic | 167 (5.2) | 53 (5.6) | 73 (4.7) | 4825 (6.2) |
| Middle Eastern | 26 (0.8) | 8 (0.8) | 14 (0.9) | 514 (0.7) |
| Native American/Alaskan Native | 0 (0.0) | 0 (0.0) | 0 (0.0) | 98 (0.1) |
| White | 2126 (66.1) | 604 (63.8) | 1025 (66.5) | 48,855 (62.5) |
| Multiple/other/unknown | 403 (12.5) | 133 (14.0) | 185 (12.0) | 9538 (12.2) |
| Histology of thyroid cancer | ||||
| Medullary | 80 (4.5) | 43 (7.4) | 21 (2.7) | — |
| Non‐medullary or NOS | 1710 (95.5) | 542 (92.6) | 753 (97.3) | — |
| Not provided | 1424 (44.3) | 362 (38.2) | 768 (49.8) | — |
| Personal history of other cancers | ||||
| Any personal history of other cancer(s) | 2267 (70.5) | — | 1542 (100.0) | — |
| Thyroid cancer first | 2103 (65.4) | — | 770 (49.9) | — |
| Other reported cancer | ||||
| Breast | 1542 (48.0) | — | 1542 (100.0) | — |
| Colorectal | 197 (6.1) | — | 59 (3.8) | — |
| Kidney | 173 (5.4) | — | 38 (2.5) | — |
| Ovarian | 155 (4.8) | — | 24 (1.6) | — |
| Uterine/endometrial | 154 (4.8) | — | 60 (3.9) | — |
| Pancreatic | 43 (1.3) | — | 10 (0.6) | — |
| Family history of cancer | ||||
| Yes | 3019 (93.9) | 928 (98.0) | 1425 (92.4) | 70,828 (90.6) |
| At least one first degree relative | 2454 (76.4) | 769 (81.2) | 1154 (74.8) | 51,510 (65.9) |
| Type of cancer in first degree relative | ||||
| Breast | 1105 (34.4) | 393 (41.5) | 548 (35.5) | 28,144 (36.0) |
| Thyroid | 413 (12.9) | 165 (17.4) | 162 (10.5) | 1685 (2.2) |
| Colorectal | 416 (12.9) | 128 (13.5) | 173 (11.2) | 6873 (8.8) |
| Ovarian | 197 (6.1) | 94 (9.9) | 70 (4.5) | 3979 (5.1) |
| Uterine/endometrial | 150 (4.7) | 46 (4.9) | 58 (3.8) | 2435 (3.1) |
| Kidney | 149 (4.6) | 45 (4.8) | 66 (4.3) | 1769 (2.3) |
a
Age at diagnosis refers to the age at thyroid cancer diagnosis for the thyroid cancer cohort, the thyroid cancer only cohort, and the thyroid and breast cancer cohort. For the breast cancer only cohort, age at diagnosis refers to the age at diagnosis of breast cancer.