TABLE 2.
Univariate analysis of risk factor for IMV among hospitalized patients with COVID‐19 (N = 161)
| Variable |
Non‐IMV N = 116 |
IMV N = 45 |
cOR (CI 95%) | p value |
|---|---|---|---|---|
| Age, median (IQR) a | 54 (46–65) | 61 (53–66) | 1.37 (1.06–1.77) | 0.02 |
| Sex | ||||
| Women | 70 (60) | 23 (51) | 0.68 (0.34–1.37) | 0.29 |
| Smoking | 36 (31) | 16 (36) | 1.23 (0.59–2.53) | 0.58 |
| Comorbidities | ||||
| Diabetes mellitus | 25 (22) | 17 (38) | 2.21 (1.04–4.66) | 0.04 |
| Hypertension | 36 (31) | 20 (44) | 1.78 (0.87–3.60) | 0.11 |
| Obesity (BMI ≥30) | 37 (32) | 16 (36) | 1.18 (0.57–2.43) | 0.66 |
| Cancer | ||||
| Hematological neoplasm (n = 157) | 30 (26) | 15 (33) | 1.37 (0.64–2.88) | 0.41 |
| Chemotherapy 30 days | ||||
| No chemotherapy | 75 (65) | 36 (80) | 1 | |
| Cytotoxic chemotherapy | 34 (29) | 7 (16) | 0.43 (0.17–1.06) | 0.07 |
| Immunotherapy or targeted therapy | 7 (6) | 2 (4) | 0.60 (0.11–3.01) | 0.53 |
| Stage of cancer (n = 142) | ||||
| Advanced disease | 50 (43) | 17 (38) | 0.77 (0.36–1.60) | 0.48 |
| Laboratory data | ||||
| Hemoglobin mg/dl (n = 159) | 12.4 (9.9–14) | 13.0 (10.7–14) | 1.03 (0.90–1.17) | 0.67 |
| Platelets ×103/μl (n = 159) | 198 (139–299) | 177 (122–290) | 0.99 (0.99–1.001) | 0.27 |
| Neutrophils ×103/μl (n = 159) | 4.0 (2.5–7.4) | 6.4 (3.4–11.0) | 1.07 (1.002–1.14) | 0.05 |
| Lymphocytes ×103/μl (n = 159) | 0.7 (0.5–1.1) | 0.7 (0.4–1.1) | 1.16 (0.88–1.52) | 0.27 |
| Serum creatinine mg/dl (n = 157) | 0.7 (0.5–0.9) | 0.8 (0.6–1.2) | 1.28 (0.79–2.05) | 0.31 |
| C‐reactive protein mg/dl (n = 129) | 9.8 (4.9–19.9) | 21.6 (12.4–27) | 1.06 (1.02–1.09) | <0.01 |
| Ferritin μg/dl (n = 80) | 77.7 (38.1–178.4) | 93.0 (43.1–137.5) | 0.99 (0.99–1.003) | 0.71 |
| LDH μmol/(h·ml) (n = 154) | 16.4 (13.4–10.4) | 23.1 (18.5–36.6) | 1.04 (1.008–1.07) | 0.01 |
| D‐Dimer mg/L (n = 141) | 1.1 (0.7–2) | 1.7 (0.9–7.5) | 1.07 (1.008–1.13) | 0.03 |
| Fibrinogen g/L (n = 121) | 4.9 (4.0–6.0) | 5.5 (4.3–6.5) | 1.03 (0.92–1.16) | 0.58 |
| Albumin g/dl (n = 154) | 3.1 (2.7–3.6) | 2.9 (2.4–3.4) | 0.47 (0.27–0.83) | <0.01 |
Abbreviations: BMI, body mass index; cOR, crude odds ratio; COVID‐19, coronavirus disease; IMV, invasive mechanical ventilation; IQR, interquartile range; LDH, lactate dehydrogenase.
a
Age was categorized into 10‐years intervals. For laboratory values median and interquartile range are reported.