Fig. 1. Study of the scope of the reaction on different aliphatic and aromatic amines. Reaction conditions: method A: 30 mol% Co2(CO)8, toluene, 220 °C, 15 bar CO, 60 min, 2.0 equiv. of thiol, 1.0 equiv. of amine, 0.3 equiv. catalyst, 15 bar CO, 220 °C. Method B: same as A, adding 1.0 equiv. of AcOH. aWhen using 1.0 equiv. of TFA, yield was 41%.
