Summary of the screening of conditions done in a flow chemistry reactor^a.

No.	Conc. (M)	Press. (bar)	T (°C)	Equiv. CO	Equiv. Cat.	R. t. (min)	Ratio 5 : 2b	Yieldc5 (%)
1d	0.25	15	220		0.3	60	60 : 40	56
2	0.25	20	220	0	1	8	60 : 40	55
3	0.25	20	220	5	0.3	8.5	48 : 52	45
4e	0.25	20	220	3	0.3	8.5	53 : 47	54
5	0.1	20	220	3	0.3	7	48 : 52	n.i.f
6	0.5	20	220	3	0.3	8	48 : 52	48
7	0.25	20	220	3	0.15	7	31 : 69	n.i.f
8	0.25	28	220	3	0.3	9	45 : 55	n.i.f
9	0.25	10	220	3	0.3	6	31 : 69	n.i.f
10	0.25	20	240	3	0.3	7	43 : 57	n.i.f
11	0.25	20	200	3	0.3	7	40 : 60	n.i.f
12g	0.25	20	220	3	0.3	7.5	57 : 43	56
13h	0.25	20	220	3	0.3	8.5i	60 : 40	55

^aAll reactions were performed with 1.0 equiv. of the amine and 2.0 equiv. of thiol (method C).

^bRatio estimated based on the integrals of well resolved ¹H NMR signals of the crude mixture.

^cIn pure product.

^dBatch reaction.

^eMethod-C.

^fIsolation was not done.

^gIncluding 1.0 equiv. of AcOH (method D).

^hLong run with 1 g of amine.

ⁱ52 min of total operation time.