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. 2021 Sep 15;11(49):30623–30634. doi: 10.1039/d1ra05948c

The antibacterial mechanism of CeO2 NMs with different doping materials against various bacterial strains.

Nanomaterials Bacterial name Mechanism
Au@CeO2 Staphylococcus aureus, Escherichia coli The near-infrared light could significantly enhance the antibacterial activity of Au@CeO2, and the photothermal effect did not dominate the enhancement47
Ce(Mn, Fe)O2 Staphylococcus aureus, Escherichia coli The zone of inhibition (antibacterial effect) increased with an increase in the concentration of the dopant (Mn, Fe) elements48
CeO2/GO Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi CeO2/GO showed the highest values; this confirmed that the interaction of GO and CeO2 as a nanocomposite enhanced the antibacterial activity49
Sm-doped CeO2 Escherichia coli, Staphylococcus aureus, Bacillus cereus and Salmonella typhi The antibacterial activity revealed that the killing efficiency of Sm-CeO2 increased with an increasing concentration of Sm3+50
CeO2–Al2O3 Pseudomonas aeruginosa, Staphyloccus aureus, Bacillus subtilis and Escherichia coli ROS generation led to cell membrane disruption, protein denaturation, and DNA losses, hindering bacterial growth51
Co-doped CeO2 Escherichia coli, Staphylococcus aureus, Bacillus cereus and Salmonella typhi The electrostatic interactions between the positively charged nanomaterial and negatively charged bacteria aided the nanomaterial to penetrate the cell wall and cause damage52
CeO2 Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa The microorganism reduction in viable number indicates loss of inhibition ability of CeO2 nanomaterials53
CeO2/CePO4 Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Salmonella typhimurium The redox switching between Ce3+ and Ce4+ in the CeO2/CePO4 nanocomposites might increase the penetrating ability of the positively charged nanocomposites through the negatively charged bacterial cell wall, causing bacterial cell damage54
Polyindole/Ag–CeO2 Staphylococcus aureus, Escherichia coli The improved antibacterial activity of the nanocomposites based on the concentration of silver ions was due to the interaction between the cell wall of the bacteria and the nanocomposites, which caused toxicity55
Zr-doped CeO2 Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus fecalis, Bacillus subtilis and Proteus vulgaris The antibacterial activity/sensitivity of the nanoparticles was associated with the different bacterial cell wall structures56