Table 4.

Bootstrap Analysis of Rabbit Aqueous Humor Time-Course of Drug Concentrations and Determination of AUC Ratio, Arithmetic Mean

Suspension	Mean	SD	90% confidence interval
NP-LV
Cmax	0.222	0.019	0.191–0.253
tmax	0.720	0.341	0.160–1.280
AUC (0–6h)	0.723	0.094	0.569–0.878
AUC (0–24h)	1.075	0.146	0.0835–1.315
MP-LV
Cmax	0.223	0.046	0.146–0.299
tmax	0.625	0.216	0.269–0.981
AUC (0–6h)	0.535	0.048	0.456–0.613
AUC (0–24h)	1.029	0.167	0.754–1.303
MP-HV
Cmax	0.310	0.023	0.2733–0.348
tmax	0.532	0.126	0.325–0.739
AUC (0–6h)	0.952	0.097	0.792–1.112
AUC (0–24h)	1.642	0.209	1.299–1.986
AUC (0–6h) ratio
MP-HV/NP-LV	1.34	0.22	0.97–1.71
MP-LV/NP-LV	0.75	0.12	0.55–0.95
MP-LV/MP-HV	0.57	0.078	0.44–0.70

The units for C_max, t_max, and AUC are μg/g, hr, and μg·hr/g, respectively.

AUC, area under the concentration time curve; SD, standard deviation.