Table 5.
Bootstrap Analysis of Rabbit Aqueous Humor Time-Course of Drug Concentrations and Determination of AUC Ratio, Geometric Mean
| Suspension | Mean | SD factor | 90% confidence interval |
|---|---|---|---|
| NP-LV | |||
| Cmax | 0.221 | 1.09 | 0.193–0.253 |
| tmax | 0.667 | 1.50 | 0.344–1.300 |
| AUC (0–6h) | 0.717 | 1.14 | 0.578–0.889 |
| AUC (0–24h) | 1.064 | 1.15 | 0.849–1.333 |
| MP-LV | |||
| Cmax | 0.218 | 1.22 | 0.157–0.304 |
| tmax | 0.596 | 1.35 | 0.363–0.977 |
| AUC (0–6h) | 0.532 | 1.09 | 0.459–0.616 |
| AUC (0–24h) | 1.013 | 1.17 | 0.779–1.318 |
| MP-HV | |||
| Cmax | 0.310 | 1.08 | 0.274–0.350 |
| tmax | 0.532 | 1.19 | 0.393–1.121 |
| AUC (0–6h) | 0.947 | 1.11 | 0.800–1.121 |
| AUC (0–24h) | 1.630 | 1.14 | 1.323–2.010 |
| AUC (0–6 h) ratio | |||
| MP-HV/NP-LV | 1.32 | 1.18 | 1.00–1.74 |
| MP-LV/NP-LV | 0.74 | 1.17 | 0.57–0.96 |
| MP-LV/MP-HV | 0.56 | 1.15 | 0.45–0.70 |
The units for Cmax, tmax, and AUC are μg/g, hr, and μg·hr/g, respectively. SD factor is the geometric standard deviation factor.