FIGURE 2.

Mechanism of viral replication inhibition by 2-deoxy-D-glucose (2-DG) in SARS-CoV-2 infected host. 1. When a person is infected with SARS-CoV-2, the inflammatory action will start in the lower respiratory tract, i.e., lung epithelial cell (magnified view) 2. Glucose provides energy in the form of adenosine triphosphate (ATP) to viral host cells via glycolysis, as well as enabling glycan formation, thus supporting the creation of glycoproteins during glycosylation which helps the virus to replicate. 3. 2-DG as a glucose antimetabolite inhibits glycolysis and glycosylation, which ultimately inhibits viral proliferation.