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. 2021 Sep 21;11(49):31098–31123. doi: 10.1039/d1ra04480j

Production and purification parameters for 90Nb.

Radioisotope 90Nb
Target material Natural and enriched zirconium oxide
Product purity >95 to 97%
Major impurities 89g/mNb, 91mNb, 92mNb, 95g/mNb, 96Nb, 87Y, 89Zr
Separation method 1 Serial ion exchange chromatography (DOWEX 50 × 8 resin (cation), AG 1 × 8 resin (anion))
- Target dissolution: 28 M HF
- (Cation exchange) 1st Nb elution: concentrated HF
- (Anion exchange) 2nd Nb elution: 1% H2O2 in 6 M HCl
Product separation yield 93 to 95%
Separation method 2 Liquid–liquid extraction
- Target dissolution: 48% HF
- Extraction solvents: 10 M HCl + saturated boric acid, 0.02 M N-benzoyl-N-phenylhydroxylamine in CHCl3, aqua regia
Product separation yield 76 to 81%
Target recovery yield n/a