Fig. 4. Pore formation by compounds 1 and 2. Typical ion current recordings at 5 and 10 μM treatment of 1 and 2 under 50 mV membrane voltage. The membrane was formed from DOPC/DOPE 2 : 1 (w/w) in n-decane/butanol (9 : 1, v/v), in a buffer containing 10 mM Tris, 1 M KCl, pH 7.4. Each current trace represents 120 s of recording. Note the different current scale for individual recordings.
