Fig. 6. The dose response curves of the semi-synthetic PUW/MIN variants (black line) in comparison to the reference natural PUW/MIN variant (grey line). Compounds with elongated FA moiety: compound 4a (A), 4b (B), and acylated PUW/MIN variants 5a (C), 5b (D), 5c (E), and 5d (F). Complex dose response curves or low cytotoxic activity prevented calculation of IC50 values for semi-synthetic variants in some cases.
