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. 2022 Apr 22;16:1159–1170. doi: 10.2147/DDDT.S343978

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© 2022 Riaz et al.

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Effects of carvacrol treatment on the morphological integrity of the joint tissues in PO-induced hyperuricemic rats. The joint tissues (n = 7 per group) were stained with H&E and then observed under 10× magnification. Scale bar = 50 µm. Saline group: 1, skin tissue; 2a and 2b, synovial fluid, 3, muscle tissue. Model group (PO treatment): 1 indicates muscle; 2 indicates skin; 3 indicates urate crystals. Blue arrows indicate inflammatory cells. Allopurinol group (10 mg/kg allopurinol treatment): 1 indicates inflammatory plasma cells (lymphocytes); 2 indicates synovial fluid; 3 indicates muscle cell. Carvacrol 20 group (20 mg/kg carvacrol treatment): 1a and 1b are moderate inflammation (acute and chronic); 2 indicates skin; 3 indicates muscle. Carvacrol 50 group (50 mg/kg carvacrol treatment): 1 indicates muscle; 2 indicates skin; 3 indicates inflammatory cells (encircled).