Table 1.

Effects of Carvacrol and Allopurinol Treatments (n = 7 per Group) on the Serum Levels of Urea, Creatinine, Uric Acid, and CRP in PO-Induced Hyperuricemic Rats

Treatment	Urea (mg/dl)	Creatinine (mg/dl)	Uric Acid (mg/dl)	CRP (mg/L)
Baseline	25.86 ± 0.79	0.276 ± 0.03	2.83 ± 0.04	1.17 ± 0.11
Saline	26.40 ± 0.87	0.29 ± 0.04	2.91 ± 0.053	1.3 ± 0.1
PO model 250mg/kg	32.0 ± 0.9##	0.379 ± 0.02##	7.19 ± 0.33###	28.6 ± 1.52###
Allopurinol 10mg/kg	28.67 ± 0.88	0.303 ± 0.008	2.53 ± 0.29***	1.63 ± 0.12***
Carvacrol 20	20.75 ± 0.48***	0.305 ± 0.04	2.43 ± 0.11***	1.77 ± 0.15***
Carvacrol 50	19.75 ± 0.63***	0.33 ± 0.04	2.01 ± 0.57***	1.75 ± 0.15***

Notes: PO (250 mg/kg) was administered to induce gout in the model group. Saline-treated rats were considered as the control group, while allopurinol-treated rats were used as the standard group. The data are presented as means ± SEM. ^###p < 0.001 and ^##p < 0.01 vs saline group, ***p < 0.001 vs model group. Mean values with dissimilar superscripts in a column significantly vary at p < 0.05.

Abbreviations: CRP, C-reactive protein; PO, potassium oxonate.