Table 3.
Clinical Manifestations and Treatments of Sporotrichosis Caused by S. globosa
| Patient | Clinical Manifestations | Risk Factor | Treatment | Outcome | Reference |
|---|---|---|---|---|---|
| 77-year-old woman (Brazil) | Verrucous lesion on the right dorsal hand with 12 ascending subcutaneous nodules on the arm, some of them fistulized | The patient handled plants, vegetable garden and soil, but did not remember local trauma | Itraconazole 100 mg/day for 5 months | Regression of all the lesions | de Oliveira et al 201023 |
| 70-year-old man (China) | Solitary, well-defined, painless, red plaque on the right forearm, with a central ulcer and yellow crusting | The patient was a greenhouse farmer with iatrogenic topical immunosuppression, and described a prior trauma with a wooden thorn | Itraconazole 200 mg/day for 4 months | Regression of the lesion | Gu et al 2020101 |
| 51-year-old man (China) | Suppurative wound and progressive subcutaneous nodules at the right arm, that became a verruca-like nodule | The patient was bitten by a stray cat | Itraconazole 200 mg/twice per day and terbinafine 250 mg/day for 1 month | Regression of the lesion | Liu et al 2020102 |
| 50-year-old woman (China) | Small mass on the right upper eyelid with rough keratinization, that often discharged purulent secretion | - | Resistant to amphotericin B, voriconazole, fluconazole, terbinafine and caspofungin Treated with itraconazole 0.2 g/twice per day for 3 months |
Regression of the lesion | Liu et al 2021103 |
| 66-year-old man (Brazil) | Scaly erythematous lesion that mimicked a sarcoid lesion with a well-demarcated ulcer in the middle of the left arm, without suppuration nor subcutaneous nodules or fistulization. | The patient was a farmer and was involved in rural activities, and described a prior trauma | Resistant to itraconazole Treated with a saturated solution of KI 1 g/day increased weekly by 1 g up to a maximum of 4 g/day for 6 months |
Regression of the lesion | Gompertz et al 2016100 |
| Mice with cutaneous infection | Soft subcutaneous lumps | - | Combination of itraconazole 60 mg/kg/day for 3 weeks, PDT at an irradiation energy density of 40 J/cm2 once every week for 3 weeks and methylene blue 2 mg/mL in the feet until they became dark blue | Reduction of the lesion and regression of the lesion in some mice at day 20 | Li et al 2019113 |
| Mice with disseminated infection | - | - | One day after infection, mice were treated once every 3 days with purified antibody against phage-KR | Increased in the survival rate (80%) | Chen et al 201998 |