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. 2022 Apr 12;13:772368. doi: 10.3389/fimmu.2022.772368

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Copyright © 2022 Zhao, Fu, Zhou, Cai, Huang, Gan, Zhang, Qian, Wang, Zhang, Wang, Xiang and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PUFAs were correlated with the chronicity of DILI. (A) The relative abundance of altered metabolite classes in recovered DILI (DILI.rec) and chronic DILI (DILI.chr) group. (B) Volcono plot of the most significant metabolite changes comparing DILI.rec with DILI.chr group. (C) Importance scores of top 20 important differential metabolites by RF between DILI.chr and DILI.rec. (D) A pathway analysis used to discover the different metabolic characteristics between DILI.rec and DILI.chr (based on SMPDB). (E) Boxplot of omega-6 PUFAs in HCs, DILI.rec and DILI.chr groups. (F) The ratios of LA/ALA and (AdA+GLA)/(EPA+DHA) between HC, DILI.rec and DILI.chr groups. (G) Serum levels of MDA and MDA/GSH-Px in HC, DILI.rec and DILI.chr groups. (H) Correlations of PUFAs with MDA and MDA/GSH-Px. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid.