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. 2022 Apr 12;13:772368. doi: 10.3389/fimmu.2022.772368

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Copyright © 2022 Zhao, Fu, Zhou, Cai, Huang, Gan, Zhang, Qian, Wang, Zhang, Wang, Xiang and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BA and PUFA metabolism related gene expression in liver of HCs and DILI patients. (A) Gene expression associated with bile acid synthesis in liver of HCs and DILI patients. (B) Altered phospholipase related gene expression in liver of DILI patients. (C) Gene expression associated with PUFA metabolism and lipid peroxidation in liver of HCs and DILI patients. (D) Verification of ELOVE5, ALOX5 and COX1 expression using qPCR. (E) A sketch map for the PUFA metabolism related enzymes (significant changes are shown as red for increase or green for decrease). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. NTCP, sodium-BA cotransporter; OATP1B, organic anion transporting polypeptide 1B; BSEP, bile salt export pump; CYP, cytochrome P450; PLA2, phospholipaseA2; PLB, phospholipase B1; FADS, fatty acid desaturase; ELOVL, elongation of very long chain fatty acids protein; ALOX, arachidonic acid lipoxygenase; COX, cyclooxygenase; TBXAS1, thromboxane synthase 1; PTGDS, prostaglandin D2 synthase; PTGES3, prostaglandin E synthase 3, LTA4, leukotriene A4; TXA2, thromboxane A2; PGG2, prostaglandin G2; PGH2, prostaglandin H2; PGD2, prostaglandin D2.