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. 2022 Apr 12;13:772368. doi: 10.3389/fimmu.2022.772368

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Copyright © 2022 Zhao, Fu, Zhou, Cai, Huang, Gan, Zhang, Qian, Wang, Zhang, Wang, Xiang and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gut microbiota profile of HCs and DILI patients. (A) The alpha diversity (observed species) index indicated the community diversity of DILI.a and DILI.b groups. (B) The beta diversity indices (unweighted wilcox) of the fecal microbiome in DILI.a and DILI.b group. (C) The relative abundance of different microbiota in HCs, DILI.a and DILI.b was shown in stacked bar chart (top 10 relevant abundance at phylum level). (D) The relative abundance of different microbiota in HCs, DILI.a and DILI.b was shown in stacked bar chart (top 5 relevant abundance at genus level). (E) Serum FGF19 levels in HC, DILI.a and DILI.b groups. (F) Cluster graph of gut microbiota function prediction using Tax4Fun (level 2). (G) Cluster graph of differential gut microbiome between HC, DILI.rec and DILI.chr at the genus level. *p < 0.05; **p < 0.01.