Table 6. Recovery of CLB as % of administered dose in different organs at various time intervals following i.v. injection of free CLB solution (CS) and CLB stealth liposomes (SL) to arthritic rats (dose 1mg/kg).
| % Recovery from Organ | Time (h) | ||||
|---|---|---|---|---|---|
| 1 | 2 | 4 | 8 | 24 | |
| CS | |||||
| Liver | 5.49± 0.52 | 10.35±0.41 | 19.22±0.14 | 28.58±0.40 | 3.435±0.45 |
| Spleen | 0.175±0.08 | 0.145±0.05 | 0.14±0.07 | 0.085±0.02 | 0.08±0.03 |
| Kidney | 2.445± 0.26 | 2.13±0.14 | 1.755±0.16 | 1.395±0.23 | 1.05±0.1 |
| Paw | 0.0095±0.01 | 0.018±0.007 | 0.012±0.002 | 0.0052±0.003 | 0.002±0.01 |
| SL | |||||
| Liver | 5.375±0.21 | 10.595±0.35 | 13.785±0.33 | 18.885±1.05 | 3.565±0.22 |
| Spleen | 1.195±0.05 | 1.905±0.02 | 2.435±0.12 | 1.905±0.08 | 0.935±0.04 |
| Kidney | 0.48±0.08 | 0.6±0.03 | 0.68±0.04 | 0.715±0.05 | 0.31±0.03 |
| Paw | 1.975±0.013 | 1.835±0.058 | 1.626±0.032 | 1.264±0.109 | 0.415±0.013 |
Data expressed as mean ± SD, n = 3