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. 2001 Apr;45(4):1008–1013. doi: 10.1128/AAC.45.4.1008-1013.2001

TABLE 1.

Microbiological study of therapeutic efficacy of GM237354 against oral candidiasis in ratsa

Total dose (mg/kg/day) Regimen (mg/kg) Day 4
Day 7
No. of infected animals/total (%) Log CFU/swab (mean ± SD) No. of infected animals/total (%) Log CFU/swab (mean ± SD)
None 13/13 (100) 4.0 ± 0.7 13/13 (100) 3.9 ± 0.6
3.75 1.25 TID 5/5 (100) 3.6 ± 0.9 4/5 (80) 2.7 ± 0.8
5 5 OD 5/5 (100) 3.7 ± 0.8 4/5 (80) 2.4 ± 0.4∗
7.5 2.5 TID 5/5 (100) 2.8 ± 0.3∗ 3/5 (60) 2.5 ± 0.3∗
10 5 BID 5/5 (100) 3.3 ± 0.5∗ 3/5 (60) 2.6 ± 0.4∗
15 5 TID 2/5 (40) 2.7 ± 0.3∗ 0/5 (0) <1.6∗∗
30 10 TID 0/5 (0) <1.6∗∗ 0/5 (0) <1.6∗∗
a

Rats were orally infected three times at 24-h intervals with 3 × 108 C. albicans 4711E cells/ml. GM237354 was administered subcutaneously once a day (OD), twice a day (BID), or TID for seven consecutive days (day 0 to day 6). The mean log CFU/swab just before treatment was 5.0 ± 0.7 (n = 43). ∗, P < 0.05; ∗∗, P < 0.01 (versus the control treatment). The limit of detection was 40 CFU/swab.