TABLE 2.

Morphometric study of therapeutic efficacy of GM237354 against oral candidiasis in rats^a

dose (mg/kg/day)	No. of infected animals/total (%)	Lh (%)	VDEh (%)	VDh (%)
None	5/5 (100)	17.5 ± 10.1	30.9 ± 5.2	6.5 ± 3.6
3.75	5/5 (100)	19.4 ± 4.9	25.6 ± 5.4	10.2 ± 2.2
7.5	5/5 (100)	4.8 ± 2.4*	13.5 ± 11.8*	3.2 ± 2.2
15	2/5 (40)	0.1 ± 0.2*	0.9 ± 1.3*	0.7 ± 1.0*
30	0/5 (0)	0	0	0

^aThe morphometric study was performed in several sections of the tongue. The animals were treated TID for 7 consecutive days. Animals treated at 30 mg/kg/day showed no tongue colonization by C. albicans. Infected animals represents the number of animals that were histologically positive for the presence of C. albicans in the epithelium. *, P < 0.05 versus the control treatment.