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. 2022 Apr 14;18(4):e1010152. doi: 10.1371/journal.pgen.1010152

Fig 8. RPM-1/FSN-1 ubiquitin ligase complex inhibits CDK-5 to control axon termination.

Fig 8

Summary showing CDK-5 is restricted by RPM-1/FSN-1 ubiquitin ligase activity in the neuronal soma. In wild-type animals (upper diagram), the RPM-1/FSN-1 ubiquitin ligase complex inhibits CDK-5 to facilitate axon termination. In rpm-1 (lf) mutants and rpm-1 LD CRISPR animals (lower diagram), the activity of the RPM-1/FSN-1 ubiquitin ligase complex is impaired and CDK-5 is not restrained. As a result, excess CDK-5 kinase activity impairs axon termination resulting in excess axon growth. CDKA-1(p35) is a known CDK-5 activator.