Table 7. Estimated causal effects of the treatment on weakness with fatigue as mediator variable.

	Pr($\mathrm{SSC}-\mathrm{W}=0$)	Pr($\mathrm{SSC}-\mathrm{W}=1$)	Pr($\mathrm{SSC}-\mathrm{W}=2$)	Pr($\mathrm{SSC}-\mathrm{W}=3$)
ACME${}^{\mathrm{a}}$ (control)	0.0539	0.00148	−0.02766	−0.02774
2.5%	0.0132	−0.00603	−0.04233	−0.04571
97.5%	0.0841	0.00893	−0.00635	−0.00599
p-Value	0.0048	0.78160	0.00400	0.01120
ACME${}^{\mathrm{a}}$ (treated)	0.0570	−0.00537	−0.02933	−0.02231
2.5%	0.0140	−0.01313	−0.04507	−0.03718
97.5%	0.0887	0.00348	−0.00749	−0.00449
p-Value	0.0040	0.25120	0.00400	0.01200
ADE${}^{\mathrm{b}}$ (control)	0.0566	0.000629	−0.0245	−0.0327
2.5%	0.0253	−0.004313	−0.0396	−0.0531
97.5%	0.0915	0.004686	−0.0101	−0.0148
p-Value	<0.0001	0.891200	<0.0001	<0.0001
ADE${}^{\mathrm{b}}$ (treated)	0.0597	−0.00622	−0.0262	−0.0273
2.5%	0.0264	−0.01240	−0.0421	−0.0450
97.5%	0.0961	−0.00123	−0.0112	−0.0127
p-Value	<0.0001	0.00560	<0.0001	<0.0001
Total effect	0.1136	−0.00474	−0.0538	−0.0550
2.5%	0.0621	−0.01327	−0.0743	−0.0802
97.5%	0.1593	0.00361	−0.0283	−0.0299
p-Value	<0.0001	0.27040	<0.0001	<0.0001

Note: The table shows nonparametric bootstrap confidence intervals based on 2500 Monte Carlo draws with the percentile method.

${}^{\mathrm{a}}$Average causal mediation effects.

${}^{\mathrm{b}}$Average direct effects.