TABLE 1.

Effect of topical treatments given twice daily for 3 days and initiated at various times postinfection on the development of orofacial herpetic cutaneous lesions in mice

Time of initiation of treatment	Treatment group	AUCa	P compared to the following treatment groupb					No. of mice with lesions/total no. of mice
			a	b	c	d	e
6 h postinfection	Untreated (a)	18.56 ± 1.59		NS	NS	<0.01	<0.01	9/9
	Gel alone (b)	19.94 ± 2.21	NS		NS	<0.01	<0.01	8/8
	Gel + 5% SLS (c)	22.31 ± 1.24	NS	NS		<0.01	<0.01	8/8
	Gel + 3% foscarnet (d)	5.28 ± 2.12	<0.01	<0.01	<0.01		<0.05	4/9d
	Gel + 3% foscarnet + 5% SLS (e)	1.80 ± 1.34	<0.01	<0.01	<0.01	<0.05		2/10d
24 h postinfection	Untreated (a)	21.50 ± 2.12		NS	NS	<0.01	<0.01	10/10
	Gel alone (b)	24.50 ± 1.69	NS		NS	<0.01	<0.01	10/10
	Gel + 5% SLS (c)	26.06 ± 2.53	NS	NS		<0.01	<0.01	8/8
	Gel + 3% foscarnet (d)	5.30 ± 2.90	<0.01	<0.01	<0.01		NS	3/10d
	Gel + 3% foscarnet + 5% SLS (e)	3.50 ± 2.34	<0.01	<0.01	<0.01	NS		2/10d
48 h postinfection	Untreated (a)	21.21 ± 2.11		NS	NS	<0.05	<0.01	12/12
	Gel alone (b)	22.29 ± 1.82	NS		NS	<0.05	<0.01	12/12
	Gel + 5% SLS (c)	18.22 ± 2.94	NS	NS		NS	<0.01	9/9
	Gel + 3% foscarnet (d)	14.14 ± 3.10	<0.05	<0.05	NS		<0.05	8/11e
	Gel + 3% foscarnet + 5% SLS (e)	6.83 ± 2.64	<0.01	<0.01	<0.01	<0.05		7/12d

^aValues are mean ± standard error of the means, calculated as [(score on day 4 + score on day 10)/2] + sum of all scores between day 4 and day 10. 

^bThe letters correspond to those given after the treatment groups in the second column. 

^cNS, not significant (i.e., P > 0.05). 

^dP < 0.01 compared to mice treated with the gel alone. 

^eP < 0.05 compared to mice treated with the gel alone.