TABLE 4.
Effects of topical treatments given twice daily for 3 days and initiated at different times postinfection on the mean titers of reactivated virus in explant cultures of ispilateral and contralateral trigeminal ganglia of latently infected mice
| Time of initiation of treatment | Treatment group | Titer of reactivated virus (mean log PFU/g of tissue ± SD)
|
No. of mice with virus reactivation in ganglia/total no. of mice
|
||
|---|---|---|---|---|---|
| Ipsilateral ganglia | Contralateral ganglia | Ipsilateral ganglia | Contralateral ganglia | ||
| 6 h postinfection | Untreated | 5.26 ± 1.46 | 3.97 ± 1.93 | 7/7 | 5/7 |
| Gel alone | 4.52 ± 1.02 | 3.92 ± 1.59 | 8/8 | 7/8 | |
| Gel + 5% SLS | 2.95 ± 1.65 | 3.22 ± 1.49 | 8/8 | 8/8 | |
| Gel + 3% foscarnet | 4.26 ± 2.02 | 2.79 ± 1.54 | 9/9 | 9/9 | |
| Gel + 3% foscarnet + 5% SLS | 3.51 ± 2.14 | 3.42 ± 1.73 | 10/10 | 7/10 | |
| 24 h postinfection | Untreated | 5.26 ± 0.38 | 4.58 ± 1.77 | 10/10 | 9/10 |
| Gel alone | 5.39 ± 0.27 | 5.41 ± 0.42 | 8/8 | 4/8 | |
| Gel + 5% SLS | 5.17 ± 0.42 | 5.70 ± 0.25 | 6/6 | 5/6 | |
| Gel + 3% foscarnet | 5.39 ± 0.81 | 3.93 ± 1.94 | 9/9 | 5/9 | |
| Gel + 3% foscarnet + 5% SLS | 4.75 ± 1.66 | 3.89 ± 1.63 | 10/10 | 7/10 | |
| 48 h postinfection | Untreated | 5.40 ± 0.21 | 3.59 ± 1.67 | 12/12 | 9/12 |
| Gel alone | 4.67 ± 0.71 | 3.43 ± 1.61 | 12/12 | 11/12 | |
| Gel + 5% SLS | 4.65 ± 0.67 | 3.68 ± 1.67 | 9/9 | 7/9 | |
| Gel + 3% foscarnet | 5.33 ± 0.61 | 3.95 ± 1.79 | 11/11 | 11/11 | |
| Gel + 3% foscarnet + 5% SLS | 4.76 ± 1.17 | 3.07 ± 1.93 | 12/12 | 9/12 | |