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Trimethoprim antagonism to PDF inhibitors
| Inhibitora | Growth of E. colib
|
|||
|---|---|---|---|---|
| IST | IST + TMP + thymidine | IST + thymidine | IST + TMP | |
| None | + | + | + | − |
| Ro 66-0376 | − | + | − | − |
| Ro 66-6976 | − | + | − | − |
30 μg/ml.
IST, Iso-Sensitest broth. The concentrations of compounds added were as follows: trimethoprim (TMP), 50 μg/ml; thymidine, 10 μg/ml. Growth of E. coli DC2 was recorded after 48 h and classified as growth (+) or no growth (−).
