Table 2.
The studies about ncRNA as diagnostic and prognostic biomarkers in SAH patients.
| Reference | Sample size | ncRNA | Platform | Sample | Findings |
|---|---|---|---|---|---|
| Su et al. [90] 2015 |
20 HC and 40 SAH | miR-132, miR-324 | Microarray and RT-qPCR | Serum | miR-132 and miR-324 were higher in SAH patients |
| Powers et al. [93] 2016 |
8 SAH | — | NanoString array and RT-qPCR | CSF | miRNA expression pattern changed over time after SAH |
| Lai et al. [91] 2017 |
10 HC and 60 SAH | miR-502-5p, miR-1297, miR-4320 | Microarray and RT-qPCR | Serum | miR-502 and miR-1297 were associated with WFNS and mRS at 9 months |
| Stylli et al. [94] 2017 |
4 HC and 20 SAH | miR-27a-3p, miR-516a-5p, miR-566, and miR-1197 | NanoString array | CSF | These miRNAs were differentially expressed between SAH patients with and without CVS |
| Lu et al. [95] 2017 |
20 HC and 40 HC | miR-4532, miR-4463, miR-1290, and miR-4793 | RT-qPCR | Plasma | 4-miRNA characterized SAH patients with DCI |
| Bache et al. [96] 2017 |
10 HC and 27 SAH | miR-21 and miR-221 | High-throughput RT-qPCR | CSF | 2 miRNAs upregulated in SAH with DCI |
| Kikkawa et al. [97] 2017 |
3 HC and 8 SAH | miR-15a | Microarray and RT-qPCR | Plasma and CSF | The dysregulation of miR-15a and KLF4 after SAH may result in CVS |
| Sheng et al. [92] 2018 |
40 HC and 128 SAH | miR-1297 | RT-qPCR | Serum | miR-1297 was associated with WFNS, Hun-Hess grade, and Fisher score and 1-year mRS |
| Pan et al. [98] 2020 |
Discovery: 10 HC and 20 SAH Validation: 65 SAH with and without CVS |
lncRNA MALAT1, lncRNA LINC01619 | RT-qPCR | CSF | These two lncRNA signatures can predict the occurrence of CVS |
Abbreviation: CSF: cerebrospinal fluid; CVS: cerebral vasospasm; DCI: delayed cerebral infraction; HC: health control; mRS: modified Rankin Scale; RT-qPCR: real-time quantitative polymerase chain reaction; SAH: subarachnoid hemorrhage; WFNS: World Federation of Neurological Surgeons.