•	Diet studies are marred by confounders, but a high-fiber diet, rich in vegetables and non-citrus fruits, coffee, and unprocessed foods may exert a protective effect on melanomagenesis
•	When using checkpoint inhibitors, probiotic use and antibiotic use was associated with worsened outcome, while high-fiber diet was associated with improved outcomes
•	Work is ongoing to identify key microbes that may be predictive of checkpoint response or therapeutic adjunct
•	Fecal microbiota transplant combined with checkpoint inhibitors has been shown to induce responses in checkpoint-inhibitor resistant melanomas in a pilot trial
•	Ongoing trials continue to evaluate the effect of changing the microbiome for melanoma treatments through dietary supplements, fecal microbiota transplant, or microbial supplements