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. 2022 May;3(5):e382–e391. doi: 10.1016/S2666-5247(21)00326-8

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© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Dose responsive inhibition of M chimaera by selected Pathogen Box compounds

MICs were determined against log phase M chimaera. M chimaera was exposed to a dilution series of each MMV compound, alongside clarithromycin and ethambutol as comparators, from 0·03 to 180 μM. Percentage survival relative to drug-free controls are plotted, where drug-free controls (not plotted) equate to 100% survival. Each data point is the mean of three biological replicates, with error bars as SD. MMV=Medicines for Malaria Venture. M chimaera=Mycobacterium chimaera. MIC=minimum inhibitory concentration.