Figure 4.

Time-kill kinetics of doxycycline, clarithromycin, ethambutol, and rifabutin against Mycobacterium chimaera

(A) Exponential phase Mycobacterium chimaera was exposed to two-times doxycycline MIC (yellow triangle) or ten-times doxycycline MIC (blue triangle). (B) Two-times clarithromycin MIC (yellow square) and ten-times clarithromycin MIC (blue square). (C) Two-times ethambutol MIC (yellow diamond) and ten-times ethambutol MIC (blue diamond). (D) Two-times rifabutin MIC (yellow hexagon) or ten-times rifabutin MIC (blue hexagon) compared with drug-free bacteria (green circle). CFU/mL were determined over 14 days. Each data point is the mean of three biological replicates with error bars as SD. MIC=minimum inhibitory concentration. CFU=colony forming unit.