Table.
MICs of commonly prescribed antimycobacterial drugs against Myobacterium chimaera, Mycobacterium tuberculosis, and Mycobacterium abscessus
| Mean MIC against M chimaera, mu;g/mL | Mean MIC against M tuberculosis, mu;g/mL | Mean MIC against M abscessus, mu;g/mL | |
|---|---|---|---|
| Aminoglycoside | |||
| Amikacin | 5·210 (1·800) | 0·195 (0)* | 10·417 (3·610) |
| Streptomycin | 3·130 (0) | 0·156 (0)* | 12·500 (0) |
| Tobramycin | 0·780 (0) | 0·200 (0)* | 10·417 (3·610) |
| Aminosalicylate | |||
| Aminosalicylic acid | 6·250 (0) | 0·390 (0)* | >200 (0) |
| Carbapenem | |||
| Imipenem | 8·333 (3·610) | 1·560 (0)* | 10·417 (3·610) |
| Diarylquinoline | |||
| Bedaquiline | 0·020 (0)* | 0·049 (0) | 0·390 (0) |
| Ethylenediamine | |||
| Ethambutol | 6·250 (0) | 3·130 (0)* | >200 (0) |
| Fluoroquinolone | |||
| Ciprofloxacin | 0·780 (0) | 0·313 (0)* | 1·560 (0) |
| Moxifloxacin | 0·200 (0)* | 0·780 (0) | 1·040 (0·45) |
| Ofloxacin | 2·607 (0·910) | 0·625 (0)* | 0·625 (0)* |
| Hydrazide | |||
| Isoniazid | >200 (0) | 0·390 (0)* | >200 (0) |
| Macrolide | |||
| Azithromycin | 10·417 (3·610)* | 83·333 (28·870) | 25·000 (0) |
| Clarithromycin | 0·390 (0)* | 1·300 (0·450) | 1·040 (0·450) |
| Erythromycin | 8·333 (3·610)* | 16·667 (5·770) | 16·667 (7·220) |
| Oxazolidinone | |||
| Linezolid | 3·130 (0) | 1·560 (0)* | 6·250 (0) |
| Phenazine | |||
| Clofazimine | 0·200 (0)* | 1·300 (0·45)* | 6·250 (0) |
| Rifamycin | |||
| Rifampicin | 0·050 (0) | 0·003 (0)* | 10·417 (3·61) |
| Rifabutin | 0·050 (0) | 0·003 (0)* | 1·560 (0) |
| Tetracycline | |||
| Doxycycline | 6·250 (0) | 3·125 (0)* | 50·000 (0) |
| Thioamide | |||
| Ethionamide | 25·000 (0) | 6·250 (0)* | >200 (0) |
Data are mean (SD) unless indicated otherwise. There was no more than one dilution difference in MICs between biological replicates. MICs were determined using the microbroth dilution method from three independent biological replicates. The table is ordered by drug class. MIC=minimum inhibitory concentration.
*
The lowest MIC value for each drug.