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. 2022 Apr 26;12(4):e817. doi: 10.1002/ctm2.817

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Genomic annotation of ucf‐eccDNAs. (A) Distribution of ucf‐eccDNAs in the indicated genomic elements. The “observed/expected ratio of genomic elements” is the number of eccDNAs falling in a certain type of genomic element divided by the percentage of the length of that genomic element over the length of the whole genome. (B) Normalised mapping ratio of eccDNA reads in specific repetitive elements (median, white dot). Gene2 kbD, 2 kb downstream of genes; Gene2 kbU, 2 kb upstream of genes; LINE, long interspersed nuclear element; LTR, long terminal repeat; ns, not significant; RC, rolling circle repeats. rDNA, ribosomal DNA repeats; scDNA, small conditional DNA repeats; SINE, short interspersed nuclear element; snDNA, small nuclear DNA repeats; srpDNA, signal recognition particle DNA repeats; tDNA, transport DNA repeats; Ucf‐eccDNAs, urinary cell‐free extrachromosomal circular deoxyribonucleic acid; UTR, untranslated region; *** and **** denote significant p values less than .001 and .0001, respectively